The establishment and development of a Comprehensive Cancer Center at the Mayo Clinic is the purpose of this grant application. The central theme of this proposal is to make the Mayo Clinic, its staff, and its patient volume strong assets in achieving the basic goals set down in the National Cancer Program. The specific objectives are, in abstract, the following: 1. To develop and enhance programs of clinical cancer research. 2. To significantly increase the number and scope of basic science cancer research programs at the Mayo Clinic. 3. To develop a coordinated program of cancer training and demonstration involving medical student, post graduate student, regional physician, and those working in cancer nursing, rehabilitation, epidamiology, and data handling. 4. To enhance development of intradisciplinary programs in cancer diagnosis and management and to make these programs productive sources of clinical research and education. 5. To expand, develop, and evaluate practical and efficient programs of cancer detection in our region. 6. To broaden the scope of Cancer Resaarch statistics at the Mayo Clinic to not only support research programs but to include such functions as community and regional cancer evaluation, monitoring of cancer rehabilitation and control, and research in cancer data handling itself. 7. To plan orderly development of our physical facilities for cancer. 8. To expand current programs and to develop new programs of service to the physician and the cancer patient in our community and our region. 9. To continue and increase our active participation in specific projects of the National Cancer Program.